Fresh Frozen Plasma (FFP)

At Uttarakhand Blood Centre, Dehradun, we provide Fresh Frozen Plasma (FFP) for patients requiring plasma transfusions. FFP contains all clotting factors and proteins essential for blood coagulation and maintaining plasma volume.

What is Fresh Frozen Plasma?

Fresh Frozen Plasma (FFP) is the liquid portion of blood that has been frozen within 8 hours of collection. It contains all coagulation factors, albumin, immunoglobulins, and other plasma proteins necessary for normal blood function.

FFP Processing and Storage

FFP is prepared through the following process:

• Whole blood is collected and centrifuged to separate plasma
• Plasma is frozen at -18°C or colder within 8 hours
• Units contain approximately 200-250 mL of plasma
• Thawed FFP can be stored at 1-6°C for up to 5 days
• Frozen FFP has a shelf life of 1 year when stored properly

Clotting Factors in FFP

FFP contains essential clotting factors including:

• Fibrinogen (Factor I)
• Prothrombin (Factor II)
• Tissue Thromboplastin (Factor III)
• Calcium (Factor IV)
• Proaccelerin (Factor V)
• Proconvertin (Factor VII)
• Antihemophilic Factor (Factor VIII)
• Christmas Factor (Factor IX)
• Stuart-Prower Factor (Factor X)
• Plasma Thromboplastin Antecedent (Factor XI)
• Hageman Factor (Factor XII)
• Fibrin Stabilizing Factor (Factor XIII)

Medical Uses of FFP

FFP transfusions are indicated for:

• Coagulation factor deficiencies (multiple factor deficiencies)
• Liver disease with coagulopathy
• Disseminated intravascular coagulation (DIC)
• Massive transfusion with dilutional coagulopathy
• Warfarin reversal when prothrombin complex concentrates unavailable
• Thrombotic thrombocytopenic purpura (TTP)
• Replacement of isolated factor deficiencies when specific concentrates unavailable

Benefits of FFP Transfusion

• Provides all coagulation factors simultaneously
• Corrects multiple clotting factor deficiencies
• Essential for liver disease patients
• Supports massive transfusion protocols
• Improves hemostasis in bleeding patients

FFP vs Other Plasma Products

Comparison with other plasma derivatives:

Emergency FFP Availability in Dehradun

Uttarakhand Blood Centre maintains frozen FFP inventory for emergency transfusions in Dehradun. We ensure rapid thawing and delivery to hospitals for critical cases including trauma, liver failure, and massive bleeding.

Quality Control and Safety

All FFP units undergo comprehensive testing:

• ABO and Rh typing verification
• Infectious disease screening (HIV, HBV, HCV, Syphilis)
• Visual inspection for clots or discoloration
• Storage temperature monitoring
• Expiry date verification

For urgent FFP requirements or plasma transfusion services in Dehradun, contact Uttarakhand Blood Centre immediately. We provide 24/7 emergency plasma support to local hospitals.